Diffusion models of protein folding
نویسندگان
چکیده
منابع مشابه
Protein Folding: Simple Models
Doublié, S., Sawaya, M.R., and Ellenberger, T. (1999). Struct. Fold. son and Beese, 2004). The same mispair, on the other Des. 7, R31–R35. hand, is poorly extended by Dpo4: it was shown to form Echols, H., and Goodman, M.F. (1991). Annu. Rev. Biochem. 60, a reverse wobble, which misaligns the 3 -end of the 477–511. primer and therefore precludes nucleophilic attack (TrinHatahet, Z., Zhou, M., R...
متن کاملSimple Models of Protein Folding
Lattice models with simplified interaction potentials have been used to analyze the ability of certain amino acid sequences to adopt a unique configuration in space [1, 2, 3]. Furthermore, phenomenological models have been used to predict protein folding kinetics amongst a subset of energetically favorable states [4, 5]. In the following, I will specifically discuss both the use of two dimensio...
متن کاملProtein folding: Does diffusion determine the folding rate?
A major question about protein folding is whether the coming together by diffusion of different segments of the polypeptide chain is rate-determining. This seemingly simple question has been very difficult to answer experimentally, but a positive result has now been obtained with one small model protein.
متن کاملCoordinate-dependent diffusion in protein folding.
Diffusion on a low-dimensional free-energy surface is a remarkably successful model for the folding dynamics of small single-domain proteins. Complicating the interpretation of both simulations and experiments is the expectation that the effective diffusion coefficient D will in general depend on the position along the folding coordinate, and this dependence may vary for different coordinates. ...
متن کاملProtein Folding: Flexible Lattice Models
In the post genomic era a possibility of theoretical prediction of protein structure from sequence of amino acids is one of the most important and challenging goals of molecular biology. High complexity of the problem requires simplification of molecular models and very efficient computational tools. Proposed here model of protein structure, dynamics and interaction scheme assumes a single inte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Physical Chemistry Chemical Physics
سال: 2011
ISSN: 1463-9076,1463-9084
DOI: 10.1039/c1cp21541h